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Showing 1 to 12 of 240 entries
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Conformational changes in receptor tyrosine kinase signaling: an ErbB garden of delights.

F1000 biology reports

Carraway KL, Kozloski GA.
PMID: 20357902
F1000 Biol Rep. 2009 Sep 28;1:72. doi: 10.3410/B1-72.

The ErbB family of receptor tyrosine kinases plays important roles in cell proliferation, differentiation, and apoptosis. Recent structural studies of these receptors have demonstrated dramatic conformational effects that are critical to their ligand binding and activation, and have shown...

Physics, biology and the right chemistry.

F1000 biology reports

Bassereau P, Goud B.
PMID: 21655337
F1000 Biol Rep. 2011;3:7. doi: 10.3410/B3-7. Epub 2011 Apr 01.

Joint studies that involve biologists and physicists are becoming more frequent and have contributed to the identification and understanding of physical parameters underlying key biological processes. Here, we illustrate the main findings resulting from a 10-year collaboration between a...

Self-incompatibility.

F1000 biology reports

Charlesworth D.
PMID: 21173841
F1000 Biol Rep. 2010 Sep 08;2:68. doi: 10.3410/B2-68.

There are several different types of self-incompatibility in different flowering plant species, and there has recently been progress in understanding their molecular genetics by using combined molecular and evolutionary approaches. Questions include the mechanism of self-incompatibility (both the nature...

Fungal echinocandin resistance.

F1000 biology reports

Munro CA.
PMID: 21173867
F1000 Biol Rep. 2010 Sep 08;2:66. doi: 10.3410/B2-66.

Echinocandins are the most recent introduction to the antifungal armamentarium and target the synthesis of β-(1,3)-glucan, the major structural polysaccharide of the fungal cell wall. Mechanisms have been identified that reduce the efficacy of the echinocandins: mutations of the...

The amygdala: inside and out.

F1000 biology reports

Hariri AR, Whalen PJ.
PMID: 21399763
F1000 Biol Rep. 2011 Jan 14;3:2. doi: 10.3410/B3-2.

Research at the interface of psychology, neuroscience, molecular biology, and genetics, focusing on the amygdala, has begun to reveal a rule book for emotional reactions. Variations in intrinsic and extrinsic factors tweak the sensitivity of the amygdala, giving rise...

The coming health crisis: indirect health effects of global climate change.

F1000 biology reports

Myers SS, Bernstein A.
PMID: 21399764
F1000 Biol Rep. 2011 Feb 01;3:3. doi: 10.3410/B3-3.

Global climate change threatens the health of hundreds of millions of people. While much has been written about the direct impacts of climate change on health as a result of more severe storms, more intense heat stress, changes in...

Chemical signaling in the gastrointestinal tract.

F1000 biology reports

Antunes LC, Davies JE, Finlay BB.
PMID: 21399765
F1000 Biol Rep. 2011 Feb 01;3:4. doi: 10.3410/B3-4.

Chemical signaling via the production of small molecules such as hormones has been studied in detail in higher organisms. These molecules have important functions in maintaining physiological homeostasis as well as allowing organisms to respond to external insults. Virtually...

Developments in low-resolution biological X-ray crystallography.

F1000 biology reports

Dyda F.
PMID: 21170372
F1000 Biol Rep. 2010 Nov 11;2:80. doi: 10.3410/B2-80.

Despite the recent substantial technological developments in X-ray crystallography, solving and refining structures at low resolutions remain substantial challenges. Many macromolecular crystals, especially those of large molecules or multicomponent assemblies, diffract X-rays to resolutions that are worse than 3.5Å....

What drives corticospinal output?.

F1000 biology reports

Lemon RN.
PMID: 21173857
F1000 Biol Rep. 2010 Jul 14;2:51. doi: 10.3410/B2-51.

Recent work has not only defined the origin of the direct cortico-motoneuronal output to the upper limb but has also identified some of the cortical networks that engage the corticospinal output during movement. A surprising finding is that some...

New templates for HIV-1 antibody-based vaccine design.

F1000 biology reports

Sattentau QJ, McMichael AJ.
PMID: 21173880
F1000 Biol Rep. 2010 Aug 09;2:60. doi: 10.3410/B2-60.

A current strategy for the design of neutralizing antibody-based vaccines to prevent HIV-1 transmission is that of reverse engineering, starting from a neutralizing antibody and working back to reconstruct its epitope by structure-based design technology. However, the field has...

Molecular evolution and genetics of postzygotic reproductive isolation in plants.

F1000 biology reports

Sweigart AL, Willis JH.
PMID: 23236340
F1000 Biol Rep. 2012;4:23. doi: 10.3410/B4-23. Epub 2012 Dec 03.

In just the last few years, plant geneticists have made tremendous progress in identifying the molecular genetic basis of postzygotic reproductive isolation. With more than a dozen genes now cloned, it is clear that plant hybrid incompatibilities usually evolve...

Putative functions of caspase-2.

F1000 biology reports

Dorstyn L, Kumar S.
PMID: 20948596
F1000 Biol Rep. 2009 Dec 15;1:96. doi: 10.3410/B1-96.

Caspase-2 is the most evolutionarily conserved of caspase family members, yet its physiological function has remained unclear and is a matter of considerable debate. Newly published data now suggest that caspase-2 is required for cell cycle regulation, repair of...

Showing 1 to 12 of 240 entries